Acetic acid in aged vinegar affects molecular targets for thrombus disease management

摘要: To elucidate the mechanism underlying action of dietary vinegar on antithrombotic activity, acetic acid, main acidic component vinegar, was used to determine antiplatelet and fibrinolytic activity. The results revealed that acid significantly inhibits adenosine diphosphate (ADP)-, collagen-, thrombin-, arachidonic (AA)-induced platelet aggregation. Acetic (2.00 mM) reduced AA-induced aggregation approximately 36.82 ± 1.31%, (0.12 mL L−1) induced by AA 30.25 1.34%. Further studies exerts its effects inhibiting cyclooxygenase-1 formation thromboxane-A2. Organic acids including formic lactic citric malic also showed activity; specifically, activity amounted 1.866 IU urokinase per mL. exerted activating plasminogen during fibrin crossing, thus leading crosslinked degradation activated plasmin. These suggest organic in play important roles prevention cure cardiovascular diseases.