Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time

摘要: Thrombosis and thromboembolic occlusions of major minor blood vessels are a complication in various peripheral vascular diseases. Antiplatelet agents (APA), key tools the treatment atherothrombosis, therefore became mainstay medication for wide range Cilostazol Ginkgo biloba extract (GB), commonly used remedies arterial disease, inhibit platelet aggregation with distinct therapeutic mechanisms. In this study, we have investigated if GB can potentiate antiplatelet effects cilostazol to explore utility combination therapy against occlusive or was evaluated alone activity using vitro vivo models. addition, potential bleeding side effect combinative assessed by measuring time, prothrombin time (PT) activated partial thromboplastin (aPTT) after oral administration. assays freshly isolated human platelets, showed superior inhibition both shear collagen-induced those each drug alone. accordance these enhanced activities, anti-thrombotic pulmonary embolism model thrombosis model. particular, increase survival rate (25 mg/kg) (20 higher more than two-fold respective drugs. Notably, did not show significant on PT aPTT increase, suggesting that may without prolongation coagulation time. With studies, suggest might offer efficacies increasing side-effects.