The relationship between tumour necrosis factor-α gene polymorphism and susceptibility and clearance of the persistent hepatitis B virus infection in a Chinese population: a meta-analysis

摘要: Abstract To date, many studies conducted in the Chinese population have determined correlation between tumour necrosis factor-α (TNF-α)-238G/A, -308G/A, -857C/T and -863C/A polymorphisms persistent hepatitis B virus (HBV) infection. However, their results remain inconclusive. With aim of confirming this correlation, we performed a meta-analysis 19 studies. The dichotomous data are presented as OR with 95% CI. our study indicate that carriers TNF-a-857T allele among pooled were more likely to show spontaneous clearance HBV (T vs C: OR=0.824, CI=0.713–0.953, p 0.009; TT CC: OR=0.701, CI=0.507–0.970, 0.032; TC OR=0.804, CI=0.683–0.947, + OR=0.835, CI=0.716–0.974, 0.021). TNF-a-308A was associated significantly reduced infection risk (A G: OR=0.585, CI=0.456–0.751, 0.002; AG GG: OR=0.519, CI=0.341–0.789, TNF-α-308G/A gene polymorphism population, whereas is TNF-α-857C/T polymorphism.