Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection.
作者： M.-H. Lu , D.-M. Tan , X.-W. Xu
DOI: 10.1111/J.1469-0691.2004.01029.X
关键词:
摘要: ABSTRACT A PCR restriction fragment length polymorphism assay was used to analyse single-nucleotide polymorphisms in the tumour necrosis factor (TNF)-α and TNF-β genes of 56 patients with chronic severe hepatitis B virus (HBV) infection, 71 who either had mild HBV infection or were asymptomatic carriers, 90 healthy controls. The serum TNF-α concentrations compared those 30 controls by radioimmunoassay. frequencies TNF1/2 genotype TNF2 allele greater than (25% vs. 11.1%, p 0.015; 12.5% 5.6%, 0.036, respectively) carriers 8.8%, 0.011; 4.2%, 0.015, respectively). Heterozygotes carrying higher levels TNFα homozygotes for wild-type among all (p
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