Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

摘要: The eradication of cancer in a patient remains an elusive challenge despite advances early detection and diagnosis, chemo- immunotherapy, pinpoint radiation treatments, expert surgical intervention. Although significant gains have been made our understanding cell biology, definite cure for most cancers does not exist at present. Thus, it is surprising that the research medical communities continue to explore importance therapeutic potential natural products their multimodality treatment approach. Curcuminoids found turmeric are one such class extensively investigated halt progression proliferation and, more important, stop metastasis from occurring. In this review, we examine curcuminoid (demethoxycurcumin [DMC]) largely because its increased stability better aqueous solubility physiological pH, unlike well-known (curcumin), which unabsorbed after oral ingestion. present review will focus on signaling pathways DMC utilizes modulate growth, invasion, cells effort provide enhanced mechanistic insight into DMC's action as pertains brain, ovarian, breast, lung, skin, prostate cancer. Additionally, attempt overview mechanism by modulating apoptosis, cycle, angiogenesis, metastasis, chemosensitivity. Lastly, hoped be gained concerning interactive role with microRNA-551a, 5' adenosine monophosphate-activated protein kinase, nuclear factor-κB, Wnt inhibitory factor-1, heat shock 70 affect