Hematopoietic progenitors and synergism of interferon-gamma and stem cell factor.

摘要: Interferon-gamma (IFN-gamma), an immunoregulatory cytokine produced by activated T cells and natural killer in response to viral infection or other stimuli, is generally recognized as a suppressor of hematopoiesis. IFN-gamma inhibited vitro colony formation granulocyte-macrophage (GM), erythroid multipotential progenitors. This exerted direct suppression on the proliferation process, but not commitment, GM The antiproliferative effects may, part, result from prolongation doubling time Clinically, may play important role pathogenesis pancytopenia aplastic anemia hemophagocytic syndrome. However, well showing inhibitory effects, increased number pure mixed megakaryocyte colonies formed post-5-fluorouracil treated bone marrow and, moreover, addition culture containing stem cell factor resulted synergistic effect development both primitive hematopoietic progenitors mature populations. These findings suggest that has bifunctional activity