Collagen cross-link metabolites in urine as markers of bone metastases in prostatic carcinoma.
作者： Kent K. Miyamoto , Susan A. McSherry , Simon P. Robins , Jeffrey M. Besterman , James L. Mohler
DOI: 10.1016/S0022-5347(17)35120-0
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摘要: AbstractThe efficacy of radionuclide bone scans in monitoring metastatic activity remains controversial. Objective measurement tumor burden would be useful for the evaluation new therapies carcinoma prostate. The recent discovery urinary excretion pyridinoline (cross-link mature collagen found cartilage and bone) deoxypyridinoline (collagen cross-link specific to measured by high pressure liquid chromatography has provided sensitive indexes breakdown rheumatoid arthritis, osteoporosis metabolic diseases.We compared deoxypyridinoline, hydroxyproline relative creatinine (nmol./mmol. creatinine) 27 patients with benign prostatic hyperplasia (patient age 70.0 ± 8.5 years, standard deviation), 29 clinically confined prostate cancer (age 9.7 years), 26 metastases 71.1 7.7 years). No diurnal variation ...
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