Personalized treatment of alcohol dependence

摘要: Pharmacogenetic and adaptive treatment approaches can be used to personalize care for alcohol-dependent patients. Preliminary evidence shows that variation in the gene encoding μ-opioid receptor moderates response naltrexone when treat alcohol dependence. Studies have also shown moderating effects of serotonin transporter on serotonergic Adaptive algorithms modify based patients’ progress promise. Initial outpatient appears a particularly important selection optimal continuing interventions. In addition, stepped-care reduce cost burden while maintaining good outcomes. Finally, matching specific problems present at intake or emerge during improve Although all these require replication further refinement, future personalized dependence bright.