Personalized medicine in psychiatry: ethical challenges and opportunities

作者:

DOI: 10.31887/DCNS.2009.11.4/KEVERS

关键词:

摘要: Pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. The prospects are exciting, but at the same time, these new techniques stand faced important scientific, ethical, legal, social challenges that need to be met order scientific advances responsibly applied. This review discusses ethical balance between challenge opportunity of under aspects adequacy, costbenefit ratio, equity. It is argued promising nature possibilities makes it all more avoid exaggerating expectations, a sophisticated infrastructure needs developed ensure realistic responsible application psychiatry.

参考文章(38)
Bryn Williams-Jones, Oonagh P Corrigan, Rhetoric and Hype Where's the 'Ethics' in Pharmacogenomics? American Journal of Pharmacogenomics. ,vol. 3, pp. 375- 383 ,(2003) , 10.2165/00129785-200303060-00004
Torsten N. Wiesel, David H. Hubel, EFFECTS OF VISUAL DEPRIVATION ON MORPHOLOGY AND PHYSIOLOGY OF CELLS IN THE CAT'S LATERAL GENICULATE BODY Journal of Neurophysiology. ,vol. 26, pp. 978- 993 ,(1963) , 10.1152/JN.1963.26.6.978
Neil Risch, Esteban Burchard, Elad Ziv, Hua Tang, Categorization of humans in biomedical research: genes, race and disease Genome Biology. ,vol. 3, pp. 1- 12 ,(2002) , 10.1186/GB-2002-3-7-COMMENT2007
L. C. Katz, C. J. Shatz, Synaptic Activity and the Construction of Cortical Circuits Science. ,vol. 274, pp. 1133- 1138 ,(1996) , 10.1126/SCIENCE.274.5290.1133
Jon Emery, Susan Hayflick, The challenge of integrating genetic medicine into primary care BMJ. ,vol. 322, pp. 1027- 1030 ,(2001) , 10.1136/BMJ.322.7293.1027
Neil A. Holtzman, Are genetic tests adequately regulated Science. ,vol. 286, pp. 409- 409 ,(1999) , 10.1126/SCIENCE.286.5439.409
Andrew Marshall, Getting the right drug into the right patient Nature Biotechnology. ,vol. 15, pp. 1249- 1252 ,(1997) , 10.1038/NBT1197-1249
Jason Lazarou, Bruce H. Pomeranz, Paul N. Corey, Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies JAMA. ,vol. 279, pp. 1200- 1205 ,(1998) , 10.1001/JAMA.279.15.1200
Elliot S. Vesell, Therapeutic Lessons from Pharmacogenetics Annals of Internal Medicine. ,vol. 126, pp. 653- 655 ,(1997) , 10.7326/0003-4819-126-8-199704150-00012
Julia Kirchheiner, Uwe Fuhr, Jürgen Brockmöller, Pharmacogenetics-based therapeutic recommendations — ready for clinical practice? Nature Reviews Drug Discovery. ,vol. 4, pp. 639- 647 ,(2005) , 10.1038/NRD1801