Pharmacogenetics-based therapeutic recommendations — ready for clinical practice?

摘要: Although considerable progress has been made in basic pharmacogenetic research, less demonstrated the application of pharmacogenetics (PGx)-based diagnostics to drug development and clinical practice. There are drugs that currently used clinic for which individualized therapy could be beneficial based on PGx data. However, specific, actionable recommendations how implement therapy--particularly with respect dosage--still have developed. Moreover, apply efficiently development, later therapy, study designs generation handling data need become more standardized. Here, we argue concise guidelines implementation analyses therapy.