Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.

摘要: Fas, also called APO-1, belongs to the tumor necrosis factor/nerve growth factor receptor family and transmits an apoptotic signal within cell by binding Fas ligand. has been implicated in activation-induced suicide of T cells cytotoxic activity immune system. Non-immune such as those liver, lung ovary express but its role these remains unclear. Ovariectomy used study homeostasis female reproductive organs, which is regulated sex hormones. Here we analyzed function ovariectomy-induced regression mouse vaginal epithelial cells. expression was detected vagina elevated after ovariectomy. Fas-deficient lpr lpr(cg) mice did not exhibit epithelia, whereas uterine induced ovariectomy affected mice. The vaginas were a persistent estrous stage with cornification judged from types fluid. Thus, appears be involved directly epithelia during cycle, suggesting that physiological this extends beyond exerted on This first evidence for inducing apoptosis non-immune