Vesicoureteric reflux: all in the genes?

摘要: Summary Vesicoureteric reflux (retrograde passage of urine from the bladder into ureter) can be secondary to outlet obstruction or a neuropathic bladder. However, most occurrences are due primary anatomical defect in junction ureter and Primary vesicoureteric is usually found during investigation urinary tract infection children, but screening shows that it present 1–2% symptom-free children. Moreover, often inherited an autosomal dominant manner, making one commonest disorders. Mutations transcription factor gene which controls prenatal development kidney have been rare syndrome includes reflux. associated with pyelonephritis, renal scarring, hypertension failure these associations may prevented by medical treatment. Early for this recommended families other affected members.