Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy.

摘要: STUDY DESIGN This study was designed to compare the effect of suppression melatonin secretion by bright light in chickens with that surgical pinealectomy. OBJECTIVE To determine whether without surgery can result scoliosis development. SUMMARY OF BACKGROUND DATA Pinealectomy consistently produces anatomic characteristics similar those human idiopathic scoliosis. Conversely, cutting pineal stalk removal gland will also addresses question constant induce formation, because it is well known 24-hour lighting conditions suppress an equivalent level as MATERIALS AND METHOD Seventy-seven newborn Nihon were separated into three groups. A control group (n = 21) no performed; a pinealectomy 15) served controls; and 41). The first two groups kept together strict 12-hour light-dark cycle, whereas third separately (>100 lux). All radiographed at weekly intervals, blood taken during middle dark cycles for serum assay using ELISA. RESULTS Fifty-four percent pinealectomized had develop 6 weeks. None constant-light or controls up 11 Measurements levels confirm suppressed. CONCLUSION suggests chickens, operation itself important challenges role isolated etiological factor development