Role of IGF-I in muscular atrophy of aging

作者: Stephen E. Borst , David T. Lowenthal

DOI: 10.1007/BF02778065

关键词:

摘要: Loss of muscle mass and strength are well-known consequences aging. The growth hormone/IGF-I pathway is both impaired with aging essential for maintenance skeletal muscle. Despite this, hormone (GH) replacement has not been effective in increasing the elderly. Possible explanations this failure include 1. The presence other age-related impairments that prevent actions GH IGF-I and 2. Complications arising from a to deliver physiologically correct manner

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