Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

摘要: It has been shown previously that slight elevations in serum levels of insulin-like growth factor-I (IGF-I) are correlated with an increased risk for developing prostate, breast, colon, and lung cancer. The aim this study was to determine the role IGF-I process stimulating tumor metastasis a mouse model colon Colon 38 adenocarcinoma tissue fragments were orthotopically transplanted by attachment surface cecum control liver-specific IGF-I-deficient (LID) mice which 25% mice. A total 156 male at 5 weeks age (74 82 LID mice) received transplants. Mice divided randomly into two groups; one group injected i.p. recombinant human (2 mg/kg) twice daily 6 weeks, other saline injections. treatment IGFBP-3 both In saline-injected group, incidence on as well frequency hepatic significantly higher compared Both treated displayed rates development liver, number metastatic nodules liver expression vascular epithelial factor (VEGF) vessel abundance tumors dependent IGF-I. This supports hypothesis circulating play important metastasis.