Effects of growth hormone and insulin-like growth factor I on renal growth and function

摘要: Polypeptide growth factors regulate kidney development, growth, and function participate in the repair processes after renal injury. The use of one or more as therapeutic agents settings acute chronic failure has been proposed. Insulin-like factor I (IGF-I) accelerates restoration normalization structure reduces mortality rates animal models mechanisms by which IGF-I acts include stimulation anabolism, maintenance glomerular filtration, acceleration tubular regeneration, increased expression ischemia-induced genes. It safely used persons at risk having patients with end-stage failure, whom it increases filtration rate. Further studies to determine role a agent for its utility medical therapy insufficiency are required.