Insulin-Like Growth Factor-I: a Key Regulator of Human Cancer Risk?

摘要: In this issue of the Journal, Ma et al. (1) report results a nested case–control study that show an association between colorectal cancer risk in men and elevated plasma levels insulin-like growth factor-I (IGF-I) decreased IGF-binding protein-3 (IGFBP-3). Importantly, demonstrates these effects by using samples drawn years before clinical appearance tumor, thus minimizing chance are influenced disease process. This follows reports demonstrating associations IGF-I and/or IGFBP-3 for cancers breast, prostate, lung, suggesting is important indicator most prevalent forms Western society (2–5). fact, appear to have stronger than other factors common cancers. unique as peptide factor. addition autocrine/paracrine functions demonstrated numerous tissues, it serves endocrine hormone promoting postnatal somatic maintaining lean tissue mass (6). modulated family high-affinity BPs. its principal carrier protein, IGFBP-3, produced primarily liver. Hepatic synthesis regulated (GH) caloric intake integrate anabolic signals from pituitary with related nutritional status. contrast insulin, which involved short-term regulation energy metabolism, changes occur over longer term days weeks. Dietary restriction, decreases serum concentration both humans rodents, reduces incidence many rodent models (7,8). Caloric excess, on hand, may increase (9). Perhaps part link diet might be due IGFBP-3. Although find little evidence measures either total or alone, they number different analyses