microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics

摘要: Breast cancer is the most common type of in women, and occurrence metastasis drastically worsens prognosis reduces overall survival. Understanding biological mechanisms that regulate transformation malignant cells, consequent metastatic transformation, immune surveillance tumor progression would contribute to development more effective targeted treatments. In this context, microRNAs (miRNAs) have proven be key regulators tumor-immune cells crosstalk for hijack immunosurveillance promote escape progression, as well modulators formation process, ranging from preparation site into migrating phenotype cells. particular, their deregulated expression has been linked aberrant oncogenes suppressor genes tumorigenesis. This review aims at summarizing role functions miRNAs involved antitumor response process breast cancer. Additionally, are promising targets gene therapy modulation potential support or inhibit specific negatively affect With perspective, recent strategies developed miRNA-based therapeutics illustrated.