Assessment of thyroid hormone activity of halogenated bisphenol A using a yeast two-hybrid assay.
作者： Masanori Terasaki , Koji Kosaka , Shoichi Kunikane , Masakazu Makino , Fujio Shiraishi
DOI: 10.1016/J.CHEMOSPHERE.2011.04.045
关键词:
摘要: Abstract The thyroid hormone agonist/antagonist activities of halogenated derivatives bisphenol A (BPA) were assessed using a yeast two-hybrid assay incorporating the human α (TRα), both with and without possible metabolic activation by rat liver S9 preparation. In absence preparation, 3,3′,5,5′-tetrabromobisphenol (TBBPA), 3,3′,5,5′-tetrachlorobisphenol (TCBPA), 3,3′,5-trichlorobisphenol (3,3′,5-triClBPA) exhibited agonist activity, whereas 3-chlorobisphenol (3-ClBPA), 3,5-dichlorobisphenol (3,5-diClBPA), 3,3′-dichlorobisphenol (3,3′-diClBPA), BPA did not. TBBPA TCBPA increased markedly (7.6-fold 3.1-fold, respectively) after their TBBPA, TCBPA, 3,3′,5-triClBPA inhibited binding triiodothyronine (T3) to TRα at 2 × 10−5 M treatment 4 × 10−6 M treatment, demonstrating T3 antagonist activity. These results revealed that significantly potential some BPAs.
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Elke Hammer, Dirk Krowas, Annett Schäfer, Michael Specht, Wittko Francke, Frieder Schauer, Isolation and Characterization of a Dibenzofuran-Degrading Yeast: Identification of Oxidation and Ring Cleavage Products Applied and Environmental Microbiology. ,vol. 64, pp. 2215- 2219 ,(1998) , 10.1128/AEM.64.6.2215-2219.1998
Daniel Zalko, Caroline Prouillac, Anne Riu, Elisabeth Perdu, Laurence Dolo, Isabelle Jouanin, Cécile Canlet, Laurent Debrauwer, Jean-Pierre Cravedi, Biotransformation of the flame retardant tetrabromo-bisphenol A by human and rat sub-cellular liver fractions Chemosphere. ,vol. 64, pp. 318- 327 ,(2006) , 10.1016/J.CHEMOSPHERE.2005.12.053
Norio. Miyaura, Akira. Suzuki, Palladium-catalyzed cross-coupling reactions of organoboron compounds Chemical Reviews. ,vol. 95, pp. 2457- 2483 ,(1995) , 10.1021/CR00039A007
Ronan Cariou, Jean-Philippe Antignac, Daniel Zalko, Alain Berrebi, Jean-Pierre Cravedi, Daniel Maume, Philippe Marchand, Fabrice Monteau, Anne Riu, François Andre, Bruno Le bizec, Exposure assessment of French women and their newborns to tetrabromobisphenol-A: Occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum Chemosphere. ,vol. 73, pp. 1036- 1041 ,(2008) , 10.1016/J.CHEMOSPHERE.2008.07.084
Stuart Harrad, Mohamed Abou-Elwafa Abdallah, Neil L. Rose, Simon D. Turner, Thomas A. Davidson, Current-use brominated flame retardants in water, sediment, and fish from English lakes. Environmental Science & Technology. ,vol. 43, pp. 9077- 9083 ,(2009) , 10.1021/ES902185U
M.F. Fernandez, J.P. Arrebola, J. Taoufiki, A. Navalón, O. Ballesteros, R. Pulgar, J.L. Vilchez, N. Olea, Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reproductive Toxicology. ,vol. 24, pp. 259- 264 ,(2007) , 10.1016/J.REPROTOX.2007.06.007
Boris Johnson-Restrepo, Douglas H. Adams, Kurunthachalam Kannan, Tetrabromobisphenol A (TBBPA) and hexabromocyclododecanes (HBCDs) in tissues of humans, dolphins, and sharks from the United States. Chemosphere. ,vol. 70, pp. 1935- 1944 ,(2008) , 10.1016/J.CHEMOSPHERE.2007.10.002
Karin Öberg, Kristofer Warman, Tomas Öberg, Distribution and levels of brominated flame retardants in sewage sludge. Chemosphere. ,vol. 48, pp. 805- 809 ,(2002) , 10.1016/S0045-6535(02)00113-3
Hidetaka Takigami, Go Suzuki, Yasuhiro Hirai, Shin-ichi Sakai, Brominated Flame Retardants and Other Polyhalogenated Compounds in Indoor Air and Dust From Two Houses in Japan Chemosphere. ,vol. 76, pp. 270- 277 ,(2009) , 10.1016/J.CHEMOSPHERE.2009.03.006
M.L. Jugan, M. Lévy-Bimbot, M. Pomérance, S. Tamisier-Karolak, J.P. Blondeau, Y. Lévi, A new bioluminescent cellular assay to measure the transcriptional effects of chemicals that modulate the alpha-1 thyroid hormone receptor. Toxicology in Vitro. ,vol. 21, pp. 1197- 1205 ,(2007) , 10.1016/J.TIV.2007.03.020