Tight junction proteins in the small intestine and prefrontal cortex of female rats exposed to stress of chronic isolation starting early in life.
作者： Natasa Hlavacova , Daniela Jezova , Magdalena Chmelova , Natalie Z. M. Homer , Peter Karailiev
DOI: 10.1111/NMO.14084
关键词:
摘要: BACKGROUND Simultaneous evaluation of barrier protein expression in the gut and brain their modulation under stress conditions have not been studied before now. As permeability function blood-brain are different both express MRs, we hypothesized that post-weaning social isolation induces changes tight junction which (1) independent (2) mediated via mineralocorticoid receptor (MR). METHODS First, using UPLC-MS/MS successfully validated selected a dose (1.2 mg/rat/day) MR antagonist spironolactone to treat female rats exposed chronic or control from postnatal day 21 for 9 weeks. KEY RESULTS Isolation caused an enhancement gene occludin ZO-1 decrease claudin-5 small intestine prefrontal cortex. failed (small intestine) (prefrontal cortex) spironolactone-treated rats. blockade resulted claudin-15 intestine. Anxiogenic effect stress, measured elevated plus-maze test, was partly prevented by treatment. CONCLUSIONS & INFERENCES Claudins, main regulators intestinal responded and/or simultaneous alterations The results suggest physiological role claudin intestine, but
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