Modulation of Morphogenesis by Egfr during Dorsal Closure in Drosophila

摘要: During Drosophila embryogenesis the process of dorsal closure (DC) results in continuity embryonic epidermis, and DC is well recognized as a model system for analysis epithelial morphogenesis wound healing. flanking lateral epidermal sheets stretch, align, fuse along midline, thereby sealing hole epidermis occupied by an extra-embryonic tissue known amnioserosa (AS). Successful requires regulation cell shape change via actomyosin contractility both AS, this involves bidirectional communication between these two tissues. We previously demonstrated that transcriptional myosin from zipper (zip) locus AS expression Ack family tyrosine kinases conjunction with Dpp secreted epidermis. A major function other species, however, negative Egfr. have, therefore, asked what role Egfr might play DC. Our studies demonstrate required to negatively regulate dpp during Interestingly, we also find signaling repress zip may be generally restrictive progression Consistent theme restricting morphogenesis, it has been shown programmed death essential proper DC, show functions inhibit or delay death. Finally, present evidence regulates promoting endocytosis AS. propose general braking mechanism on overall