Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population.
作者： D Pessayre , P Letteron , D Larrey , A Berson , M Tinel
DOI: 10.1111/J.1365-2125.1991.TB03981.X
关键词:
摘要: 1. A genetic polymorphism in human erythrocyte thiopurine methyltransferase activity (RBC TPMT) resulting a trimodal phenotypic distribution has been demonstrated both North American population and British children. 2. We studied whether such may be also present white French by testing RBC TPMT 303 randomly selected blood donors. 3. found large inter-individual variation which ranged from 2 to 40 nmol ml-1 packed h-1, with mean value of 15.4 +/- 7.0 h-1. The enzyme was not significantly influenced the sex age subjects. 4. In our sample, we no subject undetectable activity. However, probit plot log showed highly significant change slope at 7.5 Thirty four subjects (11% population) had activities below 5. These data are consistent view that described populations America United Kingdom is population, about 89% exhibiting high 11% an intermediate
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