Pattern of pS2 protein expression in premalignant and malignant lesions of gastric mucosa.

摘要: The aim of this study was to evaluate the pattern pS2 protein expression in premalignant and malignant lesions gastric epithelium. We analysed, by immunohistochemistry, six samples normal mucosa, 18 cases chronic atrophic gastritis with intestinal metaplasia (IM), 10 hyperplastic polyps, 11 adenomatous polyps 50 carcinomas, together respective adjacent non-neoplastic mucosa. is expressed throughout foveolar superficial epithelium mucosa retained out IM lesions. confined goblet cells complete occurs both columnar incomplete IM. Hyperplastic displayed significantly higher than polyps. In observed 66.0% cases, being diffuse (88.9%) type carcinomas (53.6%). A subset latter group immunoreactivity a high percentage similar that Our results demonstrate there are major changes expression, which can be used as marker gastric-type differentiation during process carcinogenesis, support existence at least two pathways transformation mucosa: one via dysplasia, leading glandular intestinal-type differentiation, other or de novo changes, displaying differentiation.