Effect of centrally injected allopregnanolone on sexual receptivity, luteinizing hormone release, hypothalamic dopamine turnover, and release in female rats.

摘要: The effect of intracerebroventricular (icv) injection allopregnanolone (5α-pregnan-3α-ol-20-one) on the dopaminergic and reproductive function in ovariectomized rats primed with estrogen progesterone was investigated. Thirty minutes after icv injection, sexual receptivity, luteinizing hormone (LH) release, dopamine content, release medial basal hypothalamus (MBH) preoptic area (POA) were determined. After LH serum levels reduced (p<0.001) lordosis behavior inhibited (p<0.005). Intracerebroventricular bicuculline (a γ-aminobutyric acidA [GABAA] antagonist) alone ineffective. plus blocked effects receptivity levels. At same time, endogenous concentration both MBH POA augmented (p<0.005 p<0.006, respectively) turnover rate decreased structures. Moreover, vitro 3H-dopamine from lower injected comparison vehicle-treated rats. These results suggest that influences mechanisms female rats, which may, turn, be responsible for activity. Allopreganolone may exert its through GABAA receptor modulation a decrease activity POA. actions could explain inhibition release.