The Value of Personalizing Medicine: Medical Oncologists' Views on Gene Expression Profiling in Breast Cancer Treatment
作者： Yvonne Bombard , Linda Rozmovits , Maureen Trudeau , Natasha B. Leighl , Ken Deal
DOI: 10.1634/THEONCOLOGIST.2014-0268
关键词:
摘要: Objectives. Guidelines recommend gene-expression profiling (GEP) tests to identify early-stage breast cancer patients who may benefit from chemotherapy. However, variation exists in oncologists’ use of GEP. We explored medical views GEP and factors impacting its clinical practice. Methods.Weusedaqualitativedesign,comprisingtelephone interviewswithmedicaloncologists(n514;10academic,4in thecommunity)recruitedthroughoncologyclinics,professional advertisements, referrals. Interviews were analyzed for anticipated emergent themes using the constant comparative method including searches fordisconfirming evidence. Results. Some oncologists considered be a tool that enhanced confidence their established approach risk assessments, whereas others described it as “critical” resolving uncertainty about whether
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