Antibodies targeting cancer stem cells: a new paradigm in immunotherapy?

摘要: Antibody targeting of cancer is showing clinical and commercial success after much intense research development over the last 30 years. They still have potential to delivery long-term cures but a shift in thinking towards stem cell (CSC) model for tumour certain impact on how antibodies are selected developed, targets they bind drugs used combination with them. CSCs been identified from many human tumours share characteristics normal cells. The ability renew, metabolically or physically protect themselves xenobiotics DNA damage range locomotory-related receptors expressed could explain observations drug resistance radiation insensitivity leading metastasis patient relapse.Targeting be strategy improve outcome therapy this not as simple it seems. Targets such CD133 EpCAM/ESA mark out cells enabling specific inter...