TIMP-2: an endogenous inhibitor of angiogenesis

摘要: Remodeling of the extracellular matrix – regulated by metalloproteinases (MMPs) and their endogenous inhibitors is an important component disease progression in many chronic states. Unchecked MMP activity can result significant tissue damage, facilitate associated with host responses to pathologic injury, such as angiogenesis. The (TIMPs) have been shown regulate activity. However, recent findings demonstrate that MMP-independent effect TIMP-2 inhibits mitogenic response human microvascular endothelial cells growth factors. This first demonstration a cell-surface signaling receptor for member TIMP family suggests functions cellular These new are integrated comprehensive model function homeostasis.