Role of embryonic factors in human implantation

摘要: Implantation biology is now at a stage where experimental science will be very productive in answering basic questions about the ability of an embryo to implant. The advancement our knowledge cytokines and growth factors has been critically important fuelling recent new understanding implantation. Specifically, increased interleukin (IL)-1 system, as well leukaemia-inhibiting factor (LIF), epidermal colony-stimulating factor-1, availability recombinant protein, specific antibodies knockout mice, have led more detailed outline implantation events. LIF IL-1 are two systems advances suggested their importance Recently, shown mice endometrial requirement for development. Although pleiotropic molecule, with many interactions multiple body tissues, uterus, concentrations elevated on day 4 pregnancy. Experiments successful consisting agonists (IL-1 alpha beta), receptors (IL-1R types I II) homologous receptor antagonist (ra), also studied. Knowledge that secretes interaction between embryonic receptor, which occur. IL-1R type plentiful epithelial cells appears interact embryonically secreted beta favour Such events vivo blocked by introduction large quantities IL-1ra, consistent hypothesis appropriate agonist level surface requisite As information each cytokine or system comes light, complete molecular steps become apparent. However, it clear no single able explain complicated necessary phenomenon redundancies. becoming increasingly apparent need evidence before full available.