Novel approaches in polyepitope T-cell vaccine development against HIV-1
作者： Larisa I Karpenko , Sergei I Bazhan , Denis V Antonets , Igor M Belyakov
DOI: 10.1586/14760584.2014.861748
关键词:
摘要: RV144 clinical trial was modestly effective in preventing HIV infection. New alternative approaches are needed to design improved HIV-1 vaccines and their delivery strategies. One of these is construction synthetic polyepitope immunogen using protective T- B-cell epitopes that can induce broadly neutralizing antibodies responses cytotoxic (CD8+ CTL) helpers (CD4+ Th) T-lymphocytes. This approach seems be promising for designing new generation against HIV-1, enables theory cope with antigenic variability, focuses immune on determinants exclude from the vaccine compound autoantibodies or enhancing infectivity. Herein, authors will focus rational T-cell immunogens delivery, including: advantages disadvantages existing epitope prediction methods; features organization immunogens, which...
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