Ovarian activity in women taking an oral contraceptive containing 20 μg ethinyl estradiol and 150 μg desogestrel: Effects of low estrogen doses during the hormone-free interval ☆ ☆☆ ★ ★★ ♢
作者： S.R. Killick , C. Fitzgerald , Ann Davis
DOI: 10.1016/S0002-9378(98)70292-3
关键词:
摘要: Abstract OBJECTIVE: We assessed the effect of low ethinyl estradiol doses given during nominally hormone-free interval Mircette™ (brand desogestrel/ethinyl and estradiol) contraceptive regimen on ovarian activity. STUDY DESIGN: In a randomized, double-blind study, healthy women received 150 μg desogestrel 20 for 21 days followed by either placebo 7 (Mircette™/placebo; N = 24) or 2 10 5 (Mircette™/ethinyl estradiol; 23). RESULTS: During cycles 3, Mircette™/placebo group had higher incidence persistent follicles (eight subjects versus three subjects) average greater maximum follicle diameter than Mircette™/ethinyl group. One subject probably ovulated in cycle 2, another luteinized unruptured follicle; no such activity was seen The study medication well tolerated, there were apparent between-group differences vaginal bleeding patterns. CONCLUSION: regimen, which includes interval, more effectively suppresses follicular with monthly estrogen dose.
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sci-hub.se 参考文章(14)
Plauchut A, Desachampts F, Taillant Ml, Hedon B, Viala Jl, Pizelle Am, Vallon Am, Cristol P, Mares P, Laffargue F, Ovarian consequences of the transient interruption of combined oral contraceptives. International Journal of Fertility. ,vol. 37, pp. 270- 276 ,(1992)
M. Mall-Haefeli, I. Werner-Zodrow, P. R. Huber, A. Edelmann, Oral contraception and ovarian function. Springer, Berlin, Heidelberg. pp. 97- 105 ,(1988) , 10.1007/978-3-642-73790-9_8
Leon Speroff, Marc A. Fritz, Clinical gynecologic endocrinology and infertility ,(1983)
EE Calle, CW Heath, HL Miracle-McMahill, RJ Coates, JM Liff, S Franceschi, R Talamini, N Chantarakul, S Koetsawang, D Rachawat, A Morabia, L Schuman, W Stewart, M Szklo, C Bain, F Schofield, V Siskind, P Band, AJ Coldman, RP Gallagher, TG Hislop, P Yang, SW Duffy, LM Kolonel, AMY Nomura, MW Oberle, HW Ory, HB Peterson, HG Wilson, PA Wingo, K Ebeling, D Kunde, P Nishan, G Colditz, N Martin, T Pardthaisong, S Silpisornkosol, C Theetranont, B Boosiri, S Chutivongse, P Jimakorn, P Virutamasen, C Wongsrichanalai, AJ McMichael, T Rohan, M Ewertz, C Paul, DCG Skegg, GFS Spears, P Boyle, T Evstifeeva, JR Daling, K Malone, EA Noonan, JL Stanford, DB Thomas, NS Weiss, E White, N Andrieu, A Brêmond, F Clavel, B Gairard, J Lansac, L Piana, R Renaud, SRP Fine, HR Cuevas, P Ontiveros, A Palet, SB Salazar, N Aristizabel, A Cuadros, A Bachelot, MG Leê, J Deacon, J Peto, CN Taylor, E Alfandary, B Modan, E Ron, GD Friedman, RA Hiatt, T Bishop, K. Kosmelj, M Primic-Zakelj, B Ravnihar, J Stare, WL Beeson, G Fraser, DS Allen, RD Bulbrook, J Cuzick, IS Fentiman, JL Hayward, DY Wang, RL Hanson, MC Leske, MC Mahoney, PC Nasca, AO Varma, AL Weinstein, TR Moller, H Olsson, J Ranstam, RA Goldbohm, PA van den Brandt, RA Apelo, J Baens, JR de la Cruz, B Javier, LB Lacaya, CA Ngelangel, C La Vecchia, E Negri, E Marbuni, M Ferraroni, M Gerber, S Richardson, C Segala, D Gatei, P Kenya, A Kungu, JG Mati, LA Brinton, R Hoover, C Schairer, R Spirtas, HP Lee, MA Rookus, FE van Leeuwen, JA Schoenberg, MD Gammon, EA Clarke, L Jones, K McPherson, A Neil, M Vessey, D. Yeates, V Beral, D Bull, B Crossley, C Hermon, S Jones, T Key, Clewis G Reeves, P Smith, R Collins, R Doll, R Peto, P Hannaford, C Kay, L Rosero-Bixby, J-M Yuan, HY Wei, T Yun, C Zhiheng, G Berry, J Cooper Booth, T Jelihovsky, R Maclennan, R Shearman, Q-S Wang, CJ Baines, AB Miller, C Wall, E Lund, H Stalsberg, A Dabancens, L Martinez, R Molina, O Salas, FE Alexander, BS Hulka, CED Chilvers, L Bernstein, RW Haile, A Paganini-Hill, MC Pike, RK Ross, G Ursin, MC Yu, HO Adami, R Bergstrom, MP Longnecker, TMN Farley, S Holck, O Meirik, Breast cancer and hormonal contraceptives: further results Contraception. ,vol. 54, pp. 1- 106 ,(1996) , 10.1016/S0010-7824(15)30002-0
Z.M. Van Der Spuy, U. Sohnius, C.A. Pienaar, R. Schall, Gonadotropin and estradiol secretion during the week of placebo therapy in oral contraceptive pill users. Contraception. ,vol. 42, pp. 597- 609 ,(1990) , 10.1016/0010-7824(90)90001-C
Jürgen Spona, Max Elstein, Wilfried Feichtinger, Helen Sullivan, Frank Lüdicke, U. Müller, Bernd Düsterberg, Shorter pill-free interval in combined oral contraceptives decreases follicular development☆ Contraception. ,vol. 54, pp. 71- 77 ,(1996) , 10.1016/0010-7824(96)00137-0
K. Fotherby, A. D. S. Caldwell, The new low dose oral contraceptives. Journal of Obstetrics and Gynaecology. ,vol. 14, pp. 327- 332 ,(1994) , 10.3109/01443619409027605
Pier Giorgio Crosignani, Giovanna Testa, Walter Vegetti, Fabio Parazzini, Ovarian activity during regular oral contraceptive use Contraception. ,vol. 54, pp. 271- 273 ,(1996) , 10.1016/S0010-7824(96)00178-3
M. J. Rosenberg, S. C. Long, Oral contraceptives and cycle control: a critical review of the literature. Advances in Contraception. ,vol. 8, pp. 35- 45 ,(1992) , 10.1007/BF01849449
C. Fitzgerald, W. Feichtinger, J. Spona, M. Elstein, F. Lüdicke, U. Müller, C. Williams, A comparison of the effects of two monophasic low dose oral contraceptives on the inhibition of ovulation. Advances in Contraception. ,vol. 10, pp. 5- 18 ,(1994) , 10.1007/BF01986524