Protective effect of methicillin-susceptible Staphylococcus aureus carriage against methicillin-resistant S. aureus acquisition in nursing homes: a prospective cross-sectional study.

摘要: Author(s): Datta, Rupak; Quan, Victor; Kim, Diane; Peterson, Ellena M; Reynolds, Courtney; Meyers, Hildy; Cheung, Michele; Huang, Susan S | Abstract: ObjectiveTo evaluate whether an ecologic inverse association exists between methicillin-susceptible Staphylococcus aureus (MSSA) prevalence and methicillin-resistant S. (MRSA) in nursing homes.MethodsWe conducted a secondary analysis of prospective cross-sectional study 26 homes across Orange County, California, from 2008-2011. Admission was assessed using bilateral nares swabs collected all new residents within 3 days admission until 100 were obtained. Point representative sample residents. Swab samples plated on 5% sheep blood agar Spectra MRSA chromogenic agar. If detected, no further tests performed. not evaluated for MSSA growth. We the point correlation linear regression testing.ResultsWe 3,806 total swabs. correlated (r = -0.40, P .09). However, negatively regardless measured among sampled -0.67, .0002) or those who did harbor -0.41, .04). This effect persisted models adjusted percentage with diabetes (β -0.73, .04), skin lesions -1.17, .002), invasive devices -1.4, .0006).ConclusionsThe minimal suggest carriage may protect against acquisition homes. The suggests competition occur during home stays.