Investigation of the Human Nasal Microbiome in Persons With Long- And Short-Term Exposure to Methicillin-Resistant Staphylococcus Aureus and Other Bacteria From the Pig Farm Environment

摘要: Since its emergence in the early 2000s, livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398 (LA-MRSA CC398) has led to an increasing number of human infections Denmark and other European countries with industrial pig production. LA-MRSA CC398 is primarily associated skin among farm workers but also increasingly recognized as a cause life-threatening disease elderly immunocompromised people. Pig may serve vehicles for spread farm-origin bacteria between farms into general population. Yet, little known about bacterial community dynamics persons long- short-term exposure environment. To gain insight this, we investigated nasal microbiomes during workweek on four CC398-positive farms, well visitors two hours before, immediately after, 48 after 1-hour visit another farm. S. carriage was quantified by means culture, composition communities through sequencing 16S rRNA gene. often carried from environment, both at work home, although lower levels home. In contrast, were subject less dramatic rapidly reversible change composition. These results suggest that be important source perhaps pathogens veterinary relevance.