A comparative study of cancer proteins in the human protein-protein interaction network

摘要: Cancer is a complex disease. So far, many genes have been reported to involve in the development of cancer. Rather than traditional approach studying individual or loci, systematic investigation cancer proteins human protein-protein interaction network may provide important biological information for uncovering molecular mechanisms and, potentially, other diseases. We explored global and local characteristics encoded by (cancer proteins) interactome. found that topology was much different from essential (essential control (control proteins). Relative proteins, tended higher degree, betweenness, shorter shortest-path distance, weaker clustering coefficient further separated into two groups (recessive dominant compared their topological features. Recessive had betweenness while degree distribution characteristic shortest path distance were also significantly different. Finally, we not randomly distributed interactome they connected strongly with each other. Our study revealed stronger relative whole recessive proteins. The results are helpful candidate gene prioritization verification, biomarker discovery, ultimately, understanding etiology at systems level.