Familial Clustering of Pulmonary Nontuberculous Mycobacterial Disease

摘要: Background Nontuberculous mycobacteria (NTM) are environmental organisms associated with pulmonary disease without person-to-person transmission. Although genetic causes of disseminated NTM infection well characterized, for most human susceptibility to have not been determined. Methods Family histories relevant characteristics were obtained as part an ongoing natural history study. Six families identified in which at least two blood relatives had NTM. A systematic review medical records extracted data and baseline demographics. Data reconfirmed by telephone interviews. Results Familial clustering was proven six families. Four the white, majority affected individuals women. The average age diagnosis 56.4 ± 10.7 years, height 167.5 8.7 cm, mean BMI 22.0 2.98 kg/m 2 . Scoliosis present 31%. Five 12 patients cystic fibrosis transmembrane conductance regulator gene variations, but none classic fibrosis. Infections caused both slow rapid growing mycobacteria, including Mycobacterium avium, intracellulare, kansasii, abscessus , massiliense members typically infected different species Conclusion We familial clusters infection, suggesting that there factors contributing host among some nodular bronchiectatic disease.