Velocity profiles in the rat cerebral microvessels measured by optical coherence tomography.
作者： Yasuhiko Satomura , Toshio Yanagida , Yasuhiro Ooi , Junji Seki , Akitoshi Seiyama
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摘要: In order to analyze cerebral hemodynamics and its change following neural activation, the cross-sectional profiles of blood flow velocity in rat pial microvessels their temporal changes were measured vivo using Doppler OCT technique (Doppler optical coherence tomography). The system used this study has axial resolution 11 microm lateral about 14 cortical tissue. distributions along vertical diameter a cranial window rats at short time intervals by scanning sampling point repeatedly. obtained arterioles parabolic any phase, although centerline pulsated heart beats with amplitude as large 50% mean velocity. It indicates that is quasi-steady laminar flow, which consistent expected for case small Reynolds number frequency parameter. stimulus-induced increase pulsation was much larger than velocity, places restriction on mechanism regulating regional volume. results showed potential measuring both high spatial resolutions up 200 microm.
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