Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

摘要: Cancer is the second leading cause of death worldwide. Edible medicinal mushrooms have been used in traditional medicine as regimes for cancer patients. Recently anti-cancer bioactive components from some isolated and their effects tested. Pleurotus ferulae, a typical edible mushroom Xinjiang China, has also to treat patients folk medicine. However, little studies reported on ferulae. This study aims extract ferulae investigate extracts. We ethanol enriched with terpenoids tested anti-tumour extracts melanoma cell line B16F10, human gastric BGC 823 immortalized epithelial mucosa GES-1 vitro murine model vivo. Cell toxicity proliferation were measured by MTT assays. cycle progression, apoptosis, caspase 3 activity, mitochondrial membrane potential (MMP), migration gene expression studied vitro. PFEC suppressed tumor growth, inhibited proliferation, arrested cells at G0/G1 phases was not toxic non-cancer cells. induced apoptosis necrosis, increased reduced MMP, prevented invasion changed genes associated cycle. delayed formation growth In conclusion, extracted exert through direct suppression invasion, demonstrating its therapeutic treatment.