The Human Microbial Metabolism of Quercetin in Different Formulations: An In Vitro Evaluation

摘要: Quercetin is one of the main dietary flavonols, but its beneficial properties in disease prevention may be limited due to scarce bioavailability. For this purpose, delivery systems have been designed enhance both stability and bioavailability bioactive compounds. This study aimed at investigating human microbial metabolism quercetin derived from unformulated phytosome-formulated through an vitro model. Both ingredients were firstly characterized for their profile native (poly)phenols, then fermented with fecal microbiota 24 h. Quantification metabolites was performed by ultra-high performance liquid chromatography coupled mass spectrometry (uHPLC-MSn) analyses. Native quercetin, compound products, appeared less prone degradation version compared during incubation. products bioaccessible colonic microbiota, resulting production phenylpropanoic acid, phenylacetic acid benzoic derivatives. The extent higher ingredient, a time-dependent manner. opened new perspectives investigate role on influencing flavonols environment, pivotal step presumed bioactivity associated intake.