Nanoplasmonic biosensor: Detection and amplification of dual bio-signatures of circulating tumor DNA
作者： Anh H. Nguyen , Sang Jun Sim
DOI: 10.1016/J.BIOS.2014.09.003
关键词:
摘要: Circulating tumor DNA (ctDNA) bearing tumor-specific mutation and methylation are promising biomarkers for noninvasive cancer assessment. However, existing methods for ctDNA detection are restricted to genetic mutations. Recently, nanoplasmonics has emerged as a platform for one-step dual detection with high sensitivity and specificity. Here we present a strategy for ultrasensitive detection of tumor-specific mutations (E542K and E545K) and methylation of ctDNA of PIK3CA gene based on localized surface plasmon …
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