Chronic myelogenous leukemia: A review

摘要: Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder with an initially course lasting for 3–5 years. It eventually transforms into accelerated and blastic phases, which are generally fatal. CML was one of the first diseases in specific chromosomal abnormality identified, t(9;22)(q34;q11) or Philadelphia chromosome. had been traditionally treated conventional chemotherapy hydroxyurea busulfan. Although these agents can achieve hematologic remissions most patients, no evidence sustained disappearance evident. Interferon alpha (IFN-α) has able to cytogenetic significant number recent studies show survival advantage patients IFN-α compared those chemotherapy. The results discussed, reasons discordance among different investigators analyzed this review. Allogeneic bone marrow transplantation (BMT) may be curative some CML. benefits limitations approach treatment also discussed alternatives compared. Other therapy, including newer chemotherapeutic agents, combinations other autologous BMT, presented. availability very sensitive techniques detection chromosome at molecular level allowed minimal residual disease. information available on measurements analyzed. Finally, we discuss phase CML, as well clinical characteristics prognosis Philadelphia-chromosome-negative