Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
作者： Rama Krishna Yadlapalli , O.P. Chourasia , Kiranmayi Vemuri , Manjula Sritharan , Ramu Sridhar Perali
DOI: 10.1016/J.BMCL.2012.02.101
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摘要: Abstract A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay antitubercular Mycobacterium tuberculosis (MTB) H37Rv Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t exhibited 70.6% 63.7% HBC growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent MTB with MIC value 0.125 μg/mL.
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