Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan.

摘要: Infection with Helicobacter pylori (H. pylori) is associated an increased risk of gastric malignant lymphoma. The chronic inflammation mucosa by H. infection induces lymphomagenesis. Although this mucosal also results in atrophic gastritis, evidence supporting the possible significance gastritis lymphomagenesis scarce. Here, to evaluate association between atrophy and lymphoma, we conducted a matched case-control study at Aichi Cancer Center focusing on attribution status pepsinogen (PG) serum levels. In total, 86 patients lymphoma (including 49 cases extranodal marginal zone mucosa-associated lymphoid tissue (MALT lymphoma) 24 diffuse large B cell (DLBCL)) 1720 non-cancer controls were included. Odds ratios (ORs) 95% confidence intervals (CIs) assessed conditional logistic regression analysis adjustment for potential confounders. Results failed show statistically significant adjusted ORs positive relative negative overall MALT DLBCL, other lymphomas 0.77 (95% CI 0.45–1.33), 0.65 (0.30–1.39), 1.03 (0.38–2.79), 0.84 (0.22–3.29), respectively. contrast, was observed (OR = 2.14, 1.30–3.54). A consistent 1.96 (1.00–3.86), 1.92 (0.74–4.95), 5.80 (1.12–30.12), These findings suggest that triggers but epithelial changes due do not inherently affect development