A case of signet-ring cell carcinoma of the lung responding to S-1 as the third therapeutic regimen
作者： Takako Hirota , Makoto Hamasaki , Taishi Harada , Masaki Fujita , Kazuki Nabeshima
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摘要: 背景．肺原発の印環細胞癌は稀な腫瘍であり，予後がよくない．抗癌剤の効果についてもまとまった臨床研究はない．症例．38歳，男性．検診で右肺の異常陰影を指摘され，受診した．右上葉の無気肺があり入院となった．気管支鏡下洗浄液の細胞診で腺癌と診断された．右中葉・下葉には癌性リンパ管症を示唆する陰影に加え，小脳虫部に転移結節があり，全身化学療法を行った．ドセタキセル+シスプラチン，イリノテカン+シスプラチンはいずれも無効で，S-1を次に選択した．S-1開始後，後腹膜の左腸腰筋外側や右副腎の転移結節が一時的ではあるが，著明に縮小した．死後剖検が行われ，印環細胞成分を有する肺原発腺癌であった．結論．胃癌に有効性が確認されているS-1の治療効果を肺原発印環細胞癌で検討する意義がある．
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sci-hub.st 参考文章(10)
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