Shared and unique mutational gene co-occurrences in cancers
作者： Junqi Liu , Di Zhao , Ruitai Fan
DOI: 10.1016/J.BBRC.2015.08.086
关键词:
摘要: Cancers are often associated with mutations in multiple genes; thus, studying the distributions of genes that harbor cancer-promoting cancer samples and their co-occurrences could provide insights into diagnostics treatment. Using data from Catalogue Somatic Mutations Cancer (COSMIC), we found mutated followed a power-law distribution. For instance, few were large number (designated as high-frequent genes), while only samples. This distribution can be all types well individual cancers. In where two or more found, genes, i.e., those frequently mutated, did not co-occur other tended to co-occur. Co-occurrences unique certain cancer; however, some shared by types. Our results revealed distinct patterns less-frequently co-occurring anti-co-occurring networks. indicated treatment strategies should adopted for patients known gene without. The latter might better treated combination drugs targeting genes. also suggested possible cross-cancer treatments, use same drug combinations, may treat cancers different histological origins.
sci-hub.se 参考文章(26)
Peilin Jia, William Pao, Zhongming Zhao, Patterns and processes of somatic mutations in nine major cancers BMC Medical Genomics. ,vol. 7, pp. 11- 11 ,(2014) , 10.1186/1755-8794-7-11
Michael B. Kastan, Jiri Bartek, Cell-cycle checkpoints and cancer Nature. ,vol. 432, pp. 316- 323 ,(2004) , 10.1038/NATURE03097
Laura Pasqualucci, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A Wells, Adina Grunn, Monica Messina, Oliver Elliot, Joseph Chan, Govind Bhagat, Amy Chadburn, Gianluca Gaidano, Charles G Mullighan, Raul Rabadan, Riccardo Dalla-Favera, Analysis of the coding genome of diffuse large B-cell lymphoma Nature Genetics. ,vol. 43, pp. 830- 837 ,(2011) , 10.1038/NG.892
Ludmil B Alexandrov, Michael R Stratton, Mutational signatures: the patterns of somatic mutations hidden in cancer genomes. Current Opinion in Genetics & Development. ,vol. 24, pp. 52- 60 ,(2014) , 10.1016/J.GDE.2013.11.014
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz, Laia Bassaganyas, Tycho Baumann, Manel Juan, Mónica López-Guerra, Dolors Colomer, José MC Tubío, Cristina López, Alba Navarro, Cristian Tornador, Marta Aymerich, María Rozman, Jesús M Hernández, Diana A Puente, José MP Freije, Gloria Velasco, Ana Gutiérrez-Fernández, Dolors Costa, Anna Carrió, Sara Guijarro, Anna Enjuanes, Lluís Hernández, Jordi Yagüe, Pilar Nicolás, Carlos M Romeo-Casabona, Heinz Himmelbauer, Ester Castillo, Juliane C Dohm, Silvia de Sanjosé, Miguel A Piris, Enrique De Alava, Jesús San Miguel, Romina Royo, Josep L Gelpí, David Torrents, Modesto Orozco, David G Pisano, Alfonso Valencia, Roderic Guigó, Mónica Bayés, Simon Heath, Marta Gut, Peter Klatt, John Marshall, Keiran Raine, Lucy A Stebbings, P Andrew Futreal, Michael R Stratton, Peter J Campbell, Ivo Gut, Armando López-Guillermo, Xavier Estivill, Emili Montserrat, Carlos López-Otín, Elías Campo, None, Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature. ,vol. 475, pp. 101- 105 ,(2011) , 10.1038/NATURE10113
Michael S Lawrence, Petar Stojanov, Paz Polak, Gregory V Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L Carter, Chip Stewart, Craig H Mermel, Steven A Roberts, Adam Kiezun, Peter S Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H Ramos, Trevor J Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M Dulak, Jens Lohr, Dan-Avi Landau, Catherine J Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A McCarroll, Jaume Mora, Ryan S Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B Gabriel, Charles WM Roberts, Jaclyn A Biegel, Kimberly Stegmaier, Adam J Bass, Levi A Garraway, Matthew Meyerson, Todd R Golub, Dmitry A Gordenin, Shamil Sunyaev, Eric S Lander, Gad Getz, None, Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature. ,vol. 499, pp. 214- 218 ,(2013) , 10.1038/NATURE12213
Wei-Hua Chen, Xing-Ming Zhao, Vera van Noort, Peer Bork, Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs PLoS Computational Biology. ,vol. 9, pp. e1003073- ,(2013) , 10.1371/JOURNAL.PCBI.1003073
A. F. Rubin, P. Green, Mutation patterns in cancer genomes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 21766- 21770 ,(2009) , 10.1073/PNAS.0912499106
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O’Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton, Patterns of somatic mutation in human cancer genomes Nature. ,vol. 446, pp. 153- 158 ,(2007) , 10.1038/NATURE05610
Zahi Mitri, Tina Constantine, Ruth O'Regan, The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy Chemotherapy Research and Practice. ,vol. 2012, pp. 743193- 743193 ,(2012) , 10.1155/2012/743193