Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
作者： G. F. Weber , S. Ashkar , M. J. Glimcher , H. Cantor
DOI: 10.1126/SCIENCE.271.5248.509
关键词:
摘要: The CD44 family of surface receptors regulates adhesion, movement, and activation normal neoplastic cells. cytokine osteopontin (Eta-1), which similar cellular functions, was found to be a protein ligand CD44. Osteopontin induces chemotaxis but not homotypic aggregation, whereas the inverse is true for interaction between carbohydrate ligand, hyaluronate. different responses cells after ligation by either or hyaluronate may account independent effects on cell migration growth. This mechanism also exploited tumor promote metastasis formation.
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