Therapeutic targeting of VEGF in the treatment of glioblastoma.

摘要: Introduction: Glioblastoma (GBM) is the most common and aggressive type of primary malignant brain tumor in adults. Despite therapy with maximal safe surgical resection, radiation temozolomide, prognosis remains poor at 14.6 months. Hence, there an urgent need for developing novel therapeutic agents. In GBMs, balance angiogenic growth factors skewed toward pro-angiogenesis VEGF identified as key factor responsible neovasculature. Targeting angiogenesis hypothesized to arrest hence attractive target. Areas covered: The purpose this review discuss pathway inhibitors, their efficacy monotherapy or combination other drugs, effects on radiographic response/assessment mechanisms resistance associated biomarkers. A short summary biological characteristics will also be provided enhance understanding inhibitors. Expert ...