Evaluation of urinary 1-hydroxypyrene, S-phenylmercapturic acid, trans,trans-muconic acid, 3-methyladenine, 3-ethyladenine, 8-hydroxy-2'-deoxyguanosine and thioethers as biomarkers of exposure to cigarette smoke.
作者： S. Feng , H. J. Roethig , Q. Liang , R. Kinser , Y. Jin
DOI: 10.1080/13547500500399730
关键词:
摘要: AbstractThe objective was to evaluate the utility of urinary 1-hydroxypyrene (1-OHP), S-phenylmercapturic acid (S-PMA), trans,trans-muconic (t,t-MA), 3-methyladenine (3-MeAd), 3-ethyladenine (3-EtAd), 8-hydroxy-2′-deoxyguanosine (8-OHdG) and thioethers as biomarkers for assessing exposure in adult smokers who switched from smoking conventional cigarettes candidate potential reduced products (PREP) or stopped smoking. Two electrically heated systems (EHCSS) were used prototype that have significant reductions a number mainstream smoke constituents measured by machines relative those cigarettes. Urine samples collected randomized, controlled, forced-switching study which 110 cigarette brand (CC1) randomly assigned five groups. The groups included CC1 group, lower-tar (CC2) EHCSS1 EHCSS2 group no smok...
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