Anabolic and Catabolic Mechanisms in End-Stage Renal Disease

摘要: Muscle wasting is a prominent feature of end-stage renal disease and associated with muscle weakness poor physical functioning. Potential reasons for include advancing age, sedentary behavior, inflammation, nutritional intake, androgen deficiency, oxidative stress, metabolic acidosis, insulin resistance. Each these conditions can be decreased protein synthesis, increased degradation, or both. The primary synthesis pathway the insulin-like growth factor-1/phosphatidyl inositol-3 kinase/Akt pathway, which results in phosphorylation mammalian target rapamycin subsequent synthesis. major degradation ubiquitin-proteasome system. This review discusses ways tips balance turnover towards catabolism mechanisms by various interventions may work to mitigate even cause anabolism.