Chronic renal failure, cachexia, and ghrelin.

摘要: Protein energy wasting is frequently observed in patients with advanced chronic renal failure and end-stage disease. Anorexia reduced food intake are critical contributing factors negatively impact on patients' survival. Ghrelin a prophagic peptide produced by the stomach acting at hypothalamic level to increase activity of orexigenic neurons. In disease, plasma levels increased as likely effect clearance. Nevertheless, significantly reduced, suggesting inflammation-mediated resistance nuclei peripheral signals. A number forms evidence show that ghrelin could be overcome administration exogenous ghrelin. Therefore, has been proposed potential strategy improve protein wasting. Preliminary data encouraging although larger prospective clinical trials needed confirm results identify those who benefit most from