Progress in cerebral transplantation of expanded neuronal stem cells.
作者： R. Mark Richardson , Helen L. Fillmore , Kathryn L. Holloway , William C. Broaddus
DOI: 10.3171/JNS.2004.100.4.0659
关键词:
摘要: Object. Given the success and limitations of human fetal primary neural tissue transplantation, neuronal stem cells (NSCs) that can be adequately expanded in culture have been focus numerous attempts to develop a superior source replacement for restorative neurosurgery. To clarify recent progress toward this goal, transplantation into adult brain NSCs, vitro before grafting, was reviewed. Methods. Neuronal from variety sources, including embryos, fetuses, bone marrow, tissue. Recent investigations each these cell types generated large body information along with great number unanswered questions regarding ability replace damaged neurons. Expanded NSCs offer many advantages over their predecessors, but also may exhibit different functional abilities as grafted cells. Because will most likely ultimately graft...
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