miR-6852 serves as a prognostic biomarker in colorectal cancer and inhibits tumor growth and metastasis by targeting TCF7.
作者： Bao‑Hong Cui , Xuan Hong
关键词:
摘要: MicroRNAs (miRs) are have been demonstrated to serve important functions in the genesis of human cancer, including colorectal cancer (CRC). The role miR-6852 CRC remains unknown. In this study, it was that underexpressed tissues compared with adjacent normal tissues. Moreover, expression negatively correlated metastasis, whereas positively patient prognosis. It revealed overexpression significantly inhibited proliferation and invasion cells. reduced cells S phase. TCF7 identified be a direct target Overexpression mRNA protein levels Furthermore, highly expressed cell lines. Finally, knockdown suppressed Taken together, results present study indicated serves as tumor suppressor through targeting TCF7.
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